OPTIM PHARMA:-
Q.1 Distribution of drug in human body is depends on its
a) Dissociation constant b) Type of dosage form in which it dispensed
c) Route of drug administration d) All of these
Q.2 Procaine can be synthesized from
a) 4-Aminobenzoic acid & 2-hydroxytriethyl amine b) Sodium p-aminobenzoate & 2-chlorotriethyl amine
c) 2-Chloroethyl ester of 4-aminobenzoic acid & diethyl amine d) All of these
Q.3 UV spectroscopy is the type of
a) Emission spectroscopy b) Absorption spectroscopy c) Vibrational spectroscopy d) None of these
Q.4 Atropine ha s least effect on
a) CNS b) Autonomic ganglia c) Liver d) CVS
Q.5 Galactorrhoea is likely occur with long term use of a drug
a) Levodopa b) Domperidone c) Metoclopramide d) Selegiline
Q.6 G-protein coupled receptors are
a) Cell membrane receptor b) Cell surface receptor c) Enzymatic receptor d) Nuclear receptor
Q.7 The starting material for the synthesis of primaquine is
a) 8-amino-6-hydroxyquinoline b) 8-amino-5-hydroxyquinoline
c) 8-amino-6-methoxyquinoline d) 8-amino-6-ethoxyquinoline
Q.8 Activation of TLC plates means
a) Spotting the sample over it
b) Saturation of TLC with mobile phase
c) Development of chromatogram
d) Removing of moisture from the adsorbent layer
Q.9 A mosquito repellent volatile oil is obtained from
a) Artemisia brevifolia b) Cymbopogon nardus c) Trachyspermum ammi d) Cymbopogon flexuosus
Q.10 Which one of the following antibodies contributes in immune response through cytolytic action?
a) IgG, IgE b) IgG, IgM c) IgA, IgM d) IgA, IgD
Q.11 When partial agonist is administered along with agonist. The effect of agonist may be
a) Potentiated b) Suppressed c) Unchanged d) Depends on the type and nature of receptor
Q.12 2-bromopyridine + Benzyl cyanide + 2-(dimethyl amino) ethyl chloride gives
a) Mepyramine b) Triprolidine c) Pheniramine d) Bromopheniramine
Q.13 In UV-Visible spectroscopy, shift in λmax toward longer wavelength is known as
a) Hyperchromic shift b) Hyspsochromic shift c) Hypochromic shift d) Bathochromic shift
Q.14 List of minimum equipments required for efficient running of pharmacy is given in schedule
a) M b) A c) N d) R
Q.15 The proteolytic enzyme obtained from plant origin is
a) Pepsin b) Diastase c) Papain d) Renin
Q.16 Cantharidin, used as counter-irritant is obtained from
a) Stem wood of santalaceae family b) Roots of piperaceae
c) Insets of meloidae family d) Aerial part of chenopodiaceae family
Q.17 All of the following are antimetabolite except
a) Methotrexate b) Thioguanine c) Procarbazene d) Cytarabine
Q.18 Which one of the following drug is likely redistributed in human body?
a) Drug with high aqueous solubility b) Drug with very low aqueous solubility
c) Intermediate aqueous solubility d) Drug with very low lipid solubility
Q.19 All of the following are tablet processing problems except
a) Roughness b) Sticking & picking c) Capping & lamination d) Double impression
Q.20 An example of thermal conductivity detector is
a) Kathrometer b) Flame ionization detector c) Electron capture detector d) Bolometer
Q.21 All of the following are biogenetically derived from tyrosine except
a) Colchicine b) Morphine c) Codein d) None of these
Q.22 Phenobarbitone is a
a) Short acting barbiturate b) Long acting barbiturate
c) Intermediate acting barbiturate d) Ultra short acting barbiturate
Q.23 Which one of the following agent should avoided in acute congestive glaucoma?
a) Carbonic anhydrase inhibitor b) β-blocker c) Miotics d) α-agonist
Q.24 Wruster process is used to coat solid particles of size range
a) 1 – 5000μm b) 5 – 5000μm c) 35 – 5000μm d) 600 - 5000μm
Q.25 Sta-Rx-1500 is used in tablet formulation as
a) Diluent b) Disintergrant c) Binder d) Glidant
Q.26 The reference standard used in ESR is
a) Trimethylsilane b) Diphenyl picryl hydrazyl c) Methyl silane d) Tstramethylsilane
Q.27 Stomatal index is used as analytical constant for identification and authentification of
a) Baark drug b) Volatile oil c) Leaf drug d) Fixed oil
Q.28“Tachyphylaxis” is related to
a) Development of tolerance due to repeated use of drug b) Development of tolerance to pharmacological related drug
c) Rapid development of tolerance d) Resistance of microorganism to inhibitory action of antimicrobials
Q.29 The education regulation of pharmacy are laid down by
a) Central government b) Pharmacy council of India c) State government d) State pharmacy council
Q.30 Avicel is used in tablet formulation as
a) Diluent b) Disintergrant c) Binder d) Glidant
Q.31 Nitrogen rule is related to
a) Mass spectroscopy b) IR spectroscopy c) UV-visible spectroscopy d) NMR spectroscopy
Q.32 Micoscopic character of quillaia saponaria is
a) Anisocytic stomata b) Thin membrane arillus c) Clothing and glandular trichomes d) Rhytidomes
Q.33 Allosteric type of enzyme inhibition may
a) Both Km value & Vmax may remained unchanged
b) Km value unchanged & Vmax decrease
c) Decrease both Km value & Vmax
d) Increase both Km value & Vmax
Q.34 Dibenzthiazepine derivative is
a) Olanzapine b) Clozapine c) Quetiapine d) Loxapine
Q.35 Which one of the following adverse effect of the drugs is very common among persons having similar genetic make-up?
a) Intolerance b) Photosensitivity c) Idiosyncrasy d) Mutagenicity
Q.36 Over use of which of the following drug may cause parkinsonism?
a) Levodopa b) Domperidone c) Imipramine d) Chlorpromazine
Q.37 The main active constituent present the eucalyptus oil is
a) Alpha-pinene b) Limonene c) 1:8 Cineole d) Menthol
Q.38 The number of NMR signal expected for CH3-CH2-Cl is
a) 3 b) 5 c) 2 d) 4
Q.39 A solution of thermolabile drug is sterilized by
a) Gaseous sterilization b) Hot air sterilization c) Bacterial proof filtration d) Autoclave
Q.40 Fifth edition of I.P. is published in the year
a) 1985 b) 1996 c) 2007 d) 2005
Q.41 Remoxipride is a
a) Benzamide b) β-aminoketone c) Fluorobutyrophenone d) Dibenzoxazepine
Q.42 Laboratory glass ware are sterilized by
a) Gaseous sterilization b) Hot air sterilization c) Autoclave d) Treating with disinfectant
Q.43 The bitter principle of nux-vomica seeds is
a) Strychniine & brucine b) Eseramine & eseroline c) Ergosine & ergocornine d) Berberine & hydrastine
Q.44 Which type of light is measured in nephalometric analysis?
a) Scattered light b) Absorbed light c) Transmitted light d) None of these
Q.45 Which one of the following drug is used for treatment of myasthenia gravis?
a) Physostigmine b) Pilocarpine c) Edrophonium d) Pyridostigmine
Q.46 Emulsifier is added in emulsion to prevent
a) Phase inversion b) Creaming c) Coalescence d) All of these
Q.47 Which one of the following drug belonging from diphenylbutylpiperidine class?
a) Penfluridol b) Haloperidol c) Resperidone d) Sulpieride
Q.48 The principle of separation in paper chromatography is mainly
a) Adsorption b) Fractionation c) Partition d) Selective adsorption
Q.49 The presence of candelabra trichomes is microscopic feature of the drug listed a to d.
a) Digitalis purpurea b) Alexandrian senna c) Datura leaves d) Verbascum Thapsus
Q.50 Which one of the drug acts directly to alter fungal cell membrane permeability?
a) Ampicillin b) Polymixin B c) Amphotericin B d) Streptomycin
Q.51 Education institutions providing pharmacy education are approved by the
a) Central government
b) Pharmacy council of India
c) Drug controller of India
d) State pharmacy council
Q.52 The material used for manufacturing of grating in IR spectrophotometer is
a) Quartz b) Glass c) Alkali halide d) Polystyrene
Q.53 All of the following agents consisting dibenz[b,f]azepine ring system except
a) Carbamazepine b) Imipramine c) Trimipramine d) Amitryptyline
Q.54 How much eugenol does the volatile oil of clove contains?
a) 15 to 20 % b) 70 to 90 % c) 10 to 13 % d) 30 to 35 %
Q.55 Which of the following binds covalently to the site specified?
a) Atenolol – Beta receptors
b) Labetalol – Alpha & beta receptors
c) Phenoxybenzamine – Alpha receptors
d) Pindolol - Beta receptors
Q.56 The standard potential of a hydrogen electrode is
a) 0 b) 1 c) 100 d) 7
Q.57 Which one of the following drug is less effective in patient suffering from liver disease?
a) Drug having higher presystemic metabolism b) Prodrug
c) Acidic drug d) Basic drug
Q.58 Metabolism of carbamazepine is proceeds mainly through
a) Acetylation b) Epoxide formation c) Sulfide formation d) Sulfoxide formation
Q.59 Saturated picric acid solution in cold water used for the detection of alkaloid is known as
a) Hager reagent b) Mayer’s reagent c) Dragendorff’ss reagent d) Wagner’s reagent
Q.60 Which one of the following electrode is used in conductivity cell?
a) Platinum electrode b) Calomel electrode c) Dropping mercury electrode d) Glass electrode
Q.61 In an ideal suspension, the sedimentation volume should be
a) Less than one b) Zero c) Equal to one d) Between zero to one
Q.62 An anticholinergics effective in noctural enuresis is
a) Pirenzepine b) Propantheline c) Flavoxate d) Drotaverine
Q.63 Shellac is a resin obtained from an inset laccifera iacca, and it is used as a
a) Colouring matter b) Coating material c) Anthelmintics d) Base of ointment
Q.64 Vaccines are sterilized at
a) 55 – 60 oC b) 134 – 138 oC c) 115 – 118 oC d) 90 – 100 oC
Q.65 Which type of molecule is less fluorescent?
a) Saturated molecule b) Unsaturated molecule c) Molecule with electron withdrawing groups d) Can’t say
Q.66 A drug represents SSRIs and 5HT2A antagonist is
a) Citalopram b) Maprotiline c) Trazodone d) Amoxapine
Q.67 Rate constant of zero-order kinetics is expressed as (C0= Initial concentration of drug in plasma, Ct = concentration of drug in plasma at
time t )
a) Ct – C0 / t b) (Co – Ct ) t c) (Co – Ct ) / t d) None of these
Q.68 Which one of the following drug included in “dope test” for athletes?
a) Propranolol b) Prazosin c) Dexamphetamine d) Diazepam
Q.69 Which one of the following parameter is important for passive diffusion of drugs from gastrointestinal tract?
a) Permeability coefficient b) Dissolution constant c) pH of absorption site d) Dissociation constant
Q.70 Polarographic maxima can be avoided by using
a) Supporting electrolyte b) Purging with nitrogen c) Gelatin d) Less potential is applied across the electrode
Q.71 Gelatin I.P. should comply with
a) Limit test for chloride b) Limit test for sulfate c) Microbial limits d) Sterility test
Q.72 Oxazepine derivative is
a) Amoxapine b) Olanzapine c) Doxepin d) Maprotiline
Q.73 An early sign of instability in an emulsion is detected by
a) Phase inversion b) Breaking c) Coalescence d) Phase separation
Q.74 Which of the following statement is correct regarding a drug exhibits elimination by zero-order kinetic?
a) Biological half-life is constant
b) Both clearance and biological half-life is constant
c) Rate of elimination is constant
d) Clearance is constant
Q.75 Some of the antihistaminic are also effective in parkinsonism because of their
a) Sedative property b) Dopaminergic activity c) Anticholinergic activity d) All of these
Q.76 General structural formula of oximes is
a) R-N=CH-OH b) R-NH-OH c) R-N=O d) R-CH=N-OH
Q.77 Dog senna an adulterant of senna which is obtained from
a) Cassia auriculata b) Cassia obovata c) Cassia fistula d) Cassia cinnamon
Q.78 An important reaction for the synthesis of amino acid from carbohydrate intermediate is transamination which requires the co-factor
a) Thiamine b) Riboflavin c) Niacin d) Pyridoxal phosphate
Q.79 Solutions of two different solids are said to isotonic if they have almost similar
a) Surface tension b) Viscosity c) Concentration d) Osmotic pressure
Q.80 Drug release from inert polymeric matrix is expressed by the
a) Hixson-Cronwell equation
b) Higuchi equation
c) Noyes-Whitney equation
d) Handerson-Hasselbatch equation
Q.81 All of the following are effective in parkinsonism except
a) Biperiden b) Procyclidine c) Trihexyphenidyl d) Propantheline
Q.82 Wool fat is the another name of
a) Bees wax b) Lanolin c) Spermaceti d) Kokum butter
Q.83 The sites of oxidative deamination are
a) Skin and pancrease b) Intestine and mammary glands c) Liver and kidney d) Lung and spleen
Q.84 Structured vehicles are added in deflocculated suspension to
a) Decrease interfacial tension b) Increase wetability c) Decrease sedimentation rate d) All of these
Q.85 All of the following are reversible cholinesterase inhibitor as well as quartenary ammonium compound except
a) Edrophonium b) Physostigmine c) Pyridostigmine d) Neostigmine
Q.86 Nernst equation is used to measure
a) Absorbance b) Turbidity c) Electrode potential d) Diffusion current
Q.87 In chromatographic analysis Rf value range from
a) 1 – 100 b) 0 – 1 c) -1 – +1 d) 0 – 10
Q.88 Anthraquinone of cascara contain mainly
a) C-glucosides b) N-glucosides c) O-glucosides d) S-glucosides
Q.89 Diphenhydramine is a
a) An amide b) Amino alkyl ether c) Amino alkyl ester d) An aldehyde
Q.90 The members of the DTAB hold the office for
a) 5 yrs b) 3 yrs c) 7 yrs d) 1 yrs
Q.91 Which one of the following is most suitable diluent for directly compressible tablet?
a) Polyvinyl pyrrolidine
b) Hydroxy propyl methyl cellulose
c) Carboxy methyl cellulose
d) Microcrystalline cellulose
Q.92 Which one of the following organ has greatest capacity to biotransform the drugs?
a) Kidney b) Skin c) Liver d) Heart
Q.93 Klunge’s test is a
a) Thalloquintest for quinines b) Bortragers test for anthraquinones
c) Legal’s test for cardenolides d) Cupraloin test for isobarbaloin
Q.94 Naproxen is synthesized from
a) 2-Methoxy naphthalene c) 4-Phenoxyacetophene c) 2-Chloronaphthalene d) Phenylhydrazine
Q.95 Most major metabolic pathways are considered mainly either anabolic or catabolic. Which of the following pathway is most correctly
considered to be amphibolic?
a) Glycolysis b) Citric acid cycle c) Gluconeogenesis d) Lipolysis
Q.96 Which of the following oil is used as non-aqueous vehicle for intramuscular injection?
a) Castor oil b) Sesame oil c) Linseed oil d) Mustard oil
Q.97 At the end point in the potentiometric titration the
a) Potential is maximum b) Change in potential in minimum
c) Potential is minimum d) Change in potential in maximum
Q.98 Creams are
a) Ointment b) Gels c) Elixir d) Emulsion
Q.99 Aspirin is preferably prepared by which method of tablet manufacturing?
a) Direct compression b) Wet granulation c) Dry granulation d) Direct compression & dry granulation
Q.100 The initial step of the citric acid cycle is
a) Condensation of acetyl-CoA with oxaloacetate
b) Coneversion of pyruvate to acetyl-CoA
c) Conversion of citrate to isocitrate
d) Formation of apha ketoglutarate catalyzed by isocitrate
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